Get Involved

Anyone interested in being a participant in one of our UCSF Sarcoidosis Research Program’s clinical studies can call and leave a message to the appropriate coordinator (see studies below). You may also email us at [email protected].

We make every attempt to return your call or email within a few days. Before a visit is scheduled, we will call you to review questions regarding your medical history to determine whether you will be eligible for the studies. You may qualify for more than one study, but are not required to participate in any or all of them. Please note that a diagnosis of sarcoidosis confirmed by biopsy is required for eligibility in these studies. If we are unable to enroll you due to certain exclusion criteria, we want you to know how grateful we are for your interest and encourage you to check back at a different time for new studies for which you may qualify.

Epigenetic T-cell Study

We are happy to announce that we are now actively recruiting for a brand new clinical research study for sarcoidosis called the “Epigenetic T-cell Study”!

This research study will analyze a type of cell that is important to the immune system, called the T cell. We are interested in epigenetic (gene expression-modifying) differences that characterize these T cells in blood and lung in sarcoidosis.

Procedures will include a blood draw, breathing tests, two chest X-rays, and a bronchoscopy to obtain samples of cells from the lungs by lavage (no biopsies involved). These procedures will be done during 3 visits to our research center at UCSF over a period of 6-7 months. Compensation will be provided.

If you have active or remitted pulmonary sarcoidosis, you may be eligible to participate in this study. Please email us at [email protected] or call Anne at (415) 476-9637 if you are interested or for more information. When you contact us, please make sure to identify which study you are interested in, and if leaving a message, please give us a best time and method to contact you. Thank you!

Sarc2.0 Study

We are also currently recruiting for the Sarc2.0 study, an observational study of people with newly diagnosed pulmonary sarcoidosis. We are hoping to gain a better understanding of the critical differences between people whose disease progresses and those who recover. There are only 2 visits at UCSF for this study over the course of 2 years. At each visit you will meet with Dr. Koth (a sarcoidosis specialist), have a chest X-ray, a blood draw, and answer some questions about your health. All participants are compensated and parking is validated. Please email [email protected] or call Anne at (415) 476-9637 for more information. When you contact us, please make sure to identify which study you are interested in, and if leaving a message, please give us a best time and method to contact you. Thank you!

Natural Killer T-cell (NKT) Study

The purpose of this study is to understand how a specific type of immune cell contributes to the lung disease sarcoidosis. Sarcoidosis is caused by abnormal inflammation of the lung and other body organs. Sarcoidosis can be debilitating and treatment is associated with significant toxicities. The type of immune cell that we are studying is called the natural killer T cell. It is found in the blood. We will study these cells from sarcoidosis patients and compare the function of these cells to those from subjects that do not have sarcoidosis. This comparison will tell us many things, including whether the overall numbers of natural killer T cells are abnormal in sarcoidosis and how they function. Since the function of natural killer T cells may be affected by other types of immune cells in the blood, we will also measure function of additional classes of B and T cells. Because natural killer T cells may contribute to the inflammation in sarcoidosis, the results from this study could be very important in finding new ways to treat sarcoidosis. Funds given to the investigators from UCSF are paying for this research.

The first study visit consists of completing questionnaires and having a blood draw. These visits usually last approximately one to two hours. Sarcoidosis subjects who have not had a pulmonary function test (PFT) within six months of the visit appointment will have the opportunity to have this test performed for free during the visit. We are also trying to better understand how sarcoidosis changes over time, so we invite participants to return at yearly intervals to complete follow-up questionnaires and have a repeat blood draw.

Enrollment complete.

Relapse Study

The natural history of sarcoidosis is characterized by disease flares, in which there is usually a significant worsening of symptoms and often requires the initiation of toxic medications that suppress the immune system. Despite the clinical significance of disease relapse, we have little understanding of their underlying pathophysiology. This gap in knowledge relates to both a dearth of translational research using longitudinal studies in sarcoidosis and a lack of biomarkers for the molecular pathways important in sarcoidosis. The focus of this study is to understand the molecular biology of sarcoidosis disease flares.

Enrollment complete.